Download Antioxidants in Therapy and Preventive Medicine by Stefan L. Marklund, Kurt Karlsson (auth.), Ingrid Emerit, PDF

By Stefan L. Marklund, Kurt Karlsson (auth.), Ingrid Emerit, Lester Packer, Christian Auclair (eds.)

Twenty years in the past, the enzyme superoxide dismutase which makes use of the superoxide radical anion as its particular substrate used to be mentioned. With this discovery used to be born a brand new clinical box, during which oxygen, useful for aerobi c 1 ife on thi s planet, needed to be cons i dered additionally when it comes to its toxicity and stresses. This prompted the quest for wisdom of energetic oxygen species in biology and drugs. Superoxide and different reactive oxygen species at the moment are implicated in lots of ailment procedures. significant advances were accomplished in the course of those prior years with admire to loose radical new release and mechanisms of loose radical motion in inflicting tissue harm. In parallel, the possibil ity of influencing unfastened radical comparable affliction procedures by means of antioxidant therapy was once studied in quite a few in vitro and in vivo platforms. This was once the original subject of a convention equipped in Paris by means of the Society at no cost Radical examine (December 9-10, 1988) which introduced jointly specialists from simple sciences and clinicians so as to evaluation the present prestige of antioxidant treatment. The convention emphasised primary methods in antioxidant motion. one of the significant subject matters have been superoxide dismutase (SOD) and occasional molecular weight elements with such task, referred to as SOD mimics. different antioxidant enzymes have been additionally thought of. Antioxidant supplementations, specifically supplements E and C, different evidently occurri ng antioxidants and vari ous synthet i c antioxidants have been incorporated within the shows as there's now a quickly constructing sequence of compounds with possibly fascinating medical applications.

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S. Karger, Basel. , 1989, Protection by recombinant human superoxide dismutase in lethal rat endotoxemia, in: "Progress in Clinical and Biological Research, Vol. 308: Second Vienna Shock Forum," G. Schlag, H. , Alan R. Liss Inc, New York, pp 913. , 1987, Oxygen radicals and lipid peroxidation in experimental shock, in: "Progress in Clinical and Biological Research, First Vienna Shock Forum, Vol. 236-A: Pathophysiological Role of Mediators and Mediator Inhibitors in Shock, G. Schlag, H. , Alan R.

9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. D. , 1981, A proposed mechanism of benzene toxicity: formation of reactive intermediates from polyphenol metabolites, Toxicol. Appl. , 59: 187. , Palmer, G. , 1969, Direct demonstration of superoxide anion production during the oxidation of reduced flavin and its catalytic decomposition by erythrocuprein, Biochem. Biophys. Res. , 36: 898. B. , 1989, Auto-oxidation of dialuric acid, divicine, and isouramii. Superoxide dependent and independent mechanism, Biochem.

D. B+ + .. B0 22 e .. oa· RADPB RADP+ NAD(P)H : Flavin oxidoreductase B2 active metB2 inactive Figure 3. Mechanism of radical introduction in protein B2 34 REFERENCES 1. P. Reichard, Interactions between deoxyribonucleotide and DNA synthesis, Ann. Rev. Biochem. 57:349 (1988). 2. P. Reichard and A. Ehrenberg, Ribonucleotide reductase- a radical enzyme, Science 221:514 (1983). 3. A. M. Sjoberg, Identification of the stable free radical tyrosine residue in ribonucleotide reductase, EMBO J. 5:2037 (1986).

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